Cardiovascular RNA Interference Therapy
نویسندگان
چکیده
منابع مشابه
Enhancement of RNA Interference Effect in P19 EC Cells by an RNA-dependent RNA Polymerase
Background: RNA interference (RNAi) is a phenomenon uses double-stranded RNA (dsRNA) to specifically inhibit gene expression. The non-specific silencing caused by interferon response to dsRNA in mammalian cells limits the potential of utilizing RNAi to study gene function. Duplexes of 21-nucleotide short interfering dsRNA (siRNA) inhibit gene expression by RNAi. In some organisms, siRNA can als...
متن کاملRNA interference therapy for the Spinocerebellar ataxias
.................................................................................................................................... 25 Introduction ............................................................................................................................... 26 Results ................................................................................................................
متن کاملan introduction to rna interference (rnai)
the discovery of rna interference (rnai) in recent years has revolutionized biological and medical research. rnai is the sequence-specific gene silencing triggered by double-stranded rna (dsrna). until a couple of years ago only biologists working with caenorhabditis elegans and plants could use rnai technology to gain insight into gene function……
متن کاملRNA interference-based nanosystems for inflammatory bowel disease therapy
Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is a chronic, recrudescent disease that invades the gastrointestinal tract, and it requires surgery or lifelong medicinal therapy. The conventional medicinal therapies for IBD, such as anti-inflammatories, glucocorticoids, and immunosuppressants, are limited because of their systemic adverse effects and tox...
متن کاملHarnessing RNA interference for therapy: the silent treatment.
RNA interference (RNAi) is a ubiquitous pathway that regulates gene expression. It uses small, imperfectly paired, double-stranded RNAs approximately 21 nucleotides long, calledmicroRNAs, that are processed from longer stem-loop transcripts.1 MicroRNAs are taken up by the cytoplasmic RNA-induced silencing complex (RISC), which removes 1 strand, leaving an unpaired strand that binds to messenger...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2013
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.113.301056